Prevalence of post-tuberculosis airflow obstruction in patients who have completed pulmonary tuberculosis treatment at two infectious disease hospitals in Zimbabwe
Abstract
Tuberculosis (TB) is a major cause of death worldwide. About two thirds of patients develop impaired pulmonary function after completion of pulmonary TB treatment. It seems a high proportion of TB deaths are due to post-TB chronic airflow obstruction but data is lacking to support this assertion.
Research question- What is the prevalence of post-tuberculosis airflow obstruction in patients who have completed pulmonary tuberculosis treatment at Wilkins and Beatrice Road Infectious Diseases Hospital (BRIDH)?
Primary objective-
To determine the prevalence of post-tuberculosis airflow obstruction in patients who have completed pulmonary tuberculosis treatment at Wilkins and BRIDH hospitals.
Secondary objectives-
1 To identify factors that may influence lung function outcomes in post-TB patients.
2 To identify the pattern of spirometry values among post-TB patients.
Design, Setting and Participants
The study was a cross-sectional study at Wilkins and BRIDH hospitals in patients who had completed 6 months of anti-TB treatment.
Sample size- Three hundred and twenty-seven patients.
Methods
Spirometry was done in patients who had completed 6 months of anti-TB treatment. Participants were recruited from Wilkins and BRIDH hospitals after an informed consent. Eligible were adults aged 18-65 years who have completed 6 months of anti-TB treatment. Those with a history of smoking, occupational exposure, asthma, COPD, interstitial lung disease and bronchiectasis were excluded.
Results
The prevalence of post-tuberculosis airflow obstruction was 65.7%. Restriction probable was found in 14.4% and normal spirometry in 19.9% of the participants. Female sex (p=0.020) and recurrent episodes of TB (p=0.026) were associated with development of post-TB airflow obstruction.
Conclusion
There is a high prevalence of post-tuberculosis airflow obstruction, with moderate obstruction according to the GOLD criteria being most prominent. Recurrent episodes of TB and female sex were associated with development of post-TB airflow obstruction.
Full Text Links
http://hdl.handle.net/10646/2692Collections
Related items
Showing items related by title, author, creator and subject.
-
Relationship between knowledge and self-care practices regarding tuberculosis treatment among clients aged 20 – 40 years at Beatrice Road Infectious Hospital outpatient clinic
Gumeyi, Shenny Caroline (2012-09-03)Tuberculosis is a worldwide public health problem with a continued increase in both morbidity and mortality. It has been compounded by HIV/AIDS pandermic. Tuberculosis is widely known to affect the most economically active ... -
Deaths from pulmonary tuberculosis in the age of chemotherapy: A restrospective analysis of 192 consecutive certified deaths
Shennan, D. H.; Robinson, E. (The Central African Journal of Medicine, 1963-04) -
The effect of multi-vitamin tablets and powdered milk: on convalescent patients who had recovered from pulmonary tuberculosis
Turnbull, A. I. L. (The Central African Journal of Medicine, 1959-05)