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dc.creatorChirenda, J.
dc.creatorMurugasampillay, S.
dc.date.accessioned2016-09-14T10:14:10Z
dc.date.accessioned2019-05-28T14:36:25Z
dc.date.available2016-09-14T10:14:10Z
dc.date.available2019-05-28T14:36:25Z
dc.date.created2016-09-14T10:14:10Z
dc.date.issued2003
dc.identifierChirenda, J. & Murugasampillay, S. (2003). Malaria and HIV co-infection: Available evidence, gaps and possible interventions. Central African Journal of Medicine. 49 (5/6): 66-71.
dc.identifier0008-9176
dc.identifierhttp://hdl.handle.net/10646/2799
dc.identifier.urihttp://zdhr.uz.ac.zw/xmlui/handle/123456789/1207
dc.description.abstractObjectives: To review the evidence of association between malaria and HI V/AIDS co-infection for purposes of developing strategies for malaria control. Design: Desktop review of literature. Setting: Harare, Zimbabwe. Main Outcome Measures: Response to treatment, development of severe malaria, malarial immunological response in HIV/AIDS positive people and incidence of malaria in HIV,'AIDS positive individuals. Results: HIV-1 infection increases the incidence q{ Plasmodium falciparum parasitaemia and is associated with the development of severe malaria, commonly anaemia, cerebral malaria and high parasite density (OR=2.56; 95% CI= 1.53 to 4.29; pcO.OOl). The efficacy of chloroquine and sulphadoxine-pyrimethamine in reducing placental malaria in HIV-1 positive pregnant women was impaired compared to HIV-I negative pregnant women. However, the situation in non-gravid HIV-1 positive people as regards efficacy of chloroquine and sulphadoxine-pyrimethamine prophylaxis is not known. Also not known is the relationship between malaria parasitaemia without symptoms and HIV-1 infection, the results of which may provide useful information regarding malaria control and prevention in HIV-1 positive people. Con elusions: HIV-1 positive people staying in malaria endemic areas are at risk of developing severe malaria. Malaria prevention using insecticide-treated bed nets and indoor residual house spraying may be the best available options for these people. Chloroquine and sulphadoxine-pyrimethamine prophylaxis require further studies to verify their efficacy, in the presence of H1V-1/A1DS infection.
dc.languageen_ZW
dc.publisherUniversity of Zimbabwe, College of Health Sciences
dc.subjectMalaria
dc.subjectHIV/AIDS
dc.subjectCo-infection
dc.titleMalaria and HIV co-infection: Available evidence, gaps and possible interventions
dc.typeArticle


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